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While much of the research on genetic damage is focused on somatic effects, such as tumour formation and embryo malformation, germ line effects may be more signi cant under low exposure in the long term. This is signi cant because it may result both from the likelihood of occurrence of genetic damage in gametes, as well as its potential effects on population viability. There is evidence that DNA repair mechanisms may not be active in gametes (Anderson & Wild, 1994). This may be one of the causes for increased embryo mortality and malformation after exposure to genotoxins. Other consequences of such restricted DNA repair, however, include heritable effects of genotoxins. These may affect the next generation directly, by causing inherited diseases such as certain forms of cancer. Alternatively, if the mutation is recessive and thus has no effect on the phenotype of the embryo, they will be passed on to subsequent generations. The effects of the accumulation of such recessive mutations may then result in increased mutational load and thus reduce population viability in the long term, issues which are discussed in greater detail in 7.

Note that (3.4) and (3.5) are identical, so that we can write fT (t) = 2 0 1 (e 1 t e 2 0 t ) 2 0 1 for t > 0, 0 > 0, 1 > 0, 2 0 = 1 . (3.6)

The most obvious constraints on human happiness are the physical limitations of nature. Supplies of oil, water and fish are limited, as are the number of radio frequencies on which to send signals and the hours of sunshine to drive solar-powered cars. There s simply not enough of most natural resources for everyone to have as much as they want.

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that the light source has been refocused or changed, after which a new master flatfield frame should be prepared. A dark frame contains the bias offset signal plus the electronic and thermal noise components that are present in the image. Bias counts are from the positive voltage applied to the CCD as required for proper digitization; electronic noises include the components contributing to the readout noise of the camera; thermal noise is due to the kinetic vibration of silicon atoms in the chip. At full and one-quarter saturation of a scientific-grade CCD camera, the bias count and noises may contribute roughly 5% and 20% of the apparent pixel amplitudes, respectively, and must be subtracted from the flat-field frame and the raw frame to restore photometrically accurate pixel values. Dark frames are prepared using the same exposure time as the raw image, but without opening the shutter. Since dark frames have low signals, a master dark frame should be prepared by averaging 9 16 dark frames together. The equation for flat-field correction is Corr. Image = M (Raw Dark) (Flat Dark)

SMG 1112/97. SMG 1118/97. (not available in the CD-ROM, can be retrieved from the ETSI archive). 49 SMG 247/98. 50 SMG 478/97, 431/97 and 432/97. 51 SMG 480/97.

The preceding output shows how the ls command line is used and lists available options. Piping the output to the less command lets you page through it. You can format the help messages into a reference card using the card command. For example:

j =1

results. The challenge for a software system is to be able to accurately match the expectations of a human user since the degree of relevance of a search contains several subjective factors such as the immediate needs of the user and the context of the search. Many of the desired characteristics for advanced search, therefore, match well with the research directions in arti cial intelligence and pattern recognition. By obtaining an awareness of individual preferences, for example, a search engine could more effectively take them into account in improving the effectiveness of search. Recognizing ranking algorithms were the weak point in competing search technology, Page and Brin introduced their own new ranking algorithm PageRank.

detect In addition, those variable environments will have an increased ability to absorb change such that effects do not occur at the higher biological levels (see below) The higher level responses (at population, community and ecosystem levels) which can be attributed to either a single stressor or multiple stressors have been well-de ned for invertebrates but less well for shes (Elliott, 1994; Walker et al, 1996; Elliott & Hemingway, 2002) Stress is de ned in this context as the cumulative, quanti able response to adverse environmental conditions or factors as the result of anthropogenic activities which results in a reduction of tness to survive at any biological level of organisation (cellular, individual, population or community) In addition, certain extreme stressors, such as a loss of habitat (McLusky et al, 1992) or over shing (North Sea QSR and Inter-Governmental Ministerial Meeting, Bergen report (Svelle et al.

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