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64 D The carbonate ion has no H+ to donate to be an acid 65 D Definition 66 E Start with the one with a pKa as near 85 as possible (H2PO4 ) To go to a higher pH, the 2 HPO4 ion is needed 67 B This is an approximation 5 2 Ka = (10 ) /05 68 A HBr is a strong acid 69 D The weak acid and weak base give a nearly neutral solution 70 C Only B and C are buffers B is acidic and C is basic 71 B Only B and C are buffers B is acidic and C is basic 72 C [OH ] = (00010 9 10 ) / = (9 10 ) 73 C K = Ksp/Ka1Ka2 74 B I yields no change 75 D Ksp = [La ] [F ] = [x][3x] = 27x Solve for x

Most major cellular nutrients are freely filterable, including glucose, amino acids, acetate, Krebs cycle intermediates, certain water-soluble vitamins, lactate, acetoacetate, -hydroxybutyrate, and many others The proximal tubule is the major site for reabsorption of the large quantities of organic nutrients filtered each day by the renal corpuscles The characteristics of glucose reabsorption described in 4 are typical of the transport processes for most nutrients In general, 1 They are actively transported (ie, can be reabsorbed up their respective electrochemical gradients) Indeed, the luminal concentration of the substances in many cases can be reduced virtually to zero (ie, reabsorption can be very close to 100% complete) The uphill step is across the luminal membrane, usually via a symporter with sodium Most are characterized as Tm systems (have an upper limit to the speed at which they can transport) These limits are usually well above the amounts normally filtered Accordingly, the kidneys return these filtered substances back to the plasma; however, because there is no opportunity to vary the amount excreted (there is none), the kidneys do not help regulate their levels in the body It is also true, however, that under abnormal conditions the plasma concentration of these substances may increase so much that the filtered load exceeds the reabsorptive Tm and large quantities are excreted in the urine Examples are glucose, acetoacetate, and -hydroxybutyrate in patients with severe uncontrolled diabetes They manifest specificity This means that a given transporter selectively takes up one or a few substrates and ignores all others However, there is not a separate transporter for every solute in the body Two or more closely related substances may use the same transporter For example, the amino acid transporters are distinct from those for glucose and other monosaccharides, but there are not 20 separate transporters, one for each amino acid Rather there is one for arginine, lysine, and ornithine; another for glutamate and aspartate; and so on Shared pathways imply that there is competition among those substances using the same transporter Practically, this means that an excess of one substance, ornithine for example, in the blood may lead to not.

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3+ 3 3 4 9 1/2 12 l/2

2 3

(This annex forms an integral part of the Implementation Agreement)

17

reNaL haNDLING OF OrGaNIC SUBStaNCeS / 65

G723 is specified in ITU Recommendation G7231, Dual-Rate Speech Coder for Multimedia Communications Transmitting at 53 and 63 Kbps The G7231 operates at either 53 or 63 Kbps Both rates are a mandatory part of the encoder and decoder The algorithm has a floating-point specification in G7231 Annex B, a silence-compression algorithm in G7231 Annex A, and an encoded signal bit-error sensitivity specification in G7231 Annex C Every 30 ms, G7231 emits either 160 or 192 bits, respectively, that characterize a voice sample with an additional delay of 75 ms due to lookahead A G7231 frame can be one of three sizes: 24 octets (63-Kbps frame), 20 octets (53-Kbps frame), or 4 octets The 4-octet frames are called SID frames and are used to specify comfort noise parameters There is no restriction on how these three frames are intermixed The two least significant bits (LSBs) of the first octet in the frame determine the frame size and codec type It is possible to switch between the two rates at any 30-ms boundary

only excess ornithine excretion but also inappropriate excretion of arginine and lysine They are inhibitable by a variety of drugs, and several monogenetic diseases are associated with loss of function in one or more of these proximal reabsorptive systems In some cases, the deficit may be highly specific (eg, involving only one amino acid), whereas in others multiple systems may be involved (eg, glucose and many amino acids) This range of defects is also seen when the deficit is due to an ingested toxin (eg, heavy metal toxicity) rather than a genetic abnormality

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